Group XVI - Proteoglycans

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

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SIGNAL SEQUENCE

 

   

FREM1               MNSLSWGAANAVLLLLLLAWA

 

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CSPG

 

FREM1 (CSPG1)      -----TNSAEFVLHVEVFPVNDEPPVLKADLM--PVMNCSEG--GEVVITSEYIFATDVD

FREM1 (CSPG2)      -----KHKILKTISVEVIPVNDEKPMLSKKAE--IAMNM--G--ETRIISSAILSAIDED

FREM1 (CSPG3)      -----HHSLEIPFSIIINPTNDEAPDFVVQN---I--TVCEG--QMKELDSSIISAVDLD

FREM1 (CSPG4)      -----HHSIRHKFPINVLPKDDSP-PFLITN---VVIELEEG--QTILIQGSMLRASDVD

FREM1 (CSPG5)      -----NLSVPQVATIHITPVDDQLPKEAPGVS--RHLVVKET--EVAYITKKQLHFIDSE

FREM1 (CSPG6)      -----VWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNG-CYGIYITSRVLKASDPD

FREM1 (CSPG7)      -----NRSPALDCQITIKDMEKGDIVILTKP----LVVSKGD---RGFLTTTTLLAVDGT

FREM1 (CSPG8)      YKSESAWLPVY----IRAGIPNQIPKAAFMA----VFILEVDQFILTSLTTSVLDCEEDE

FREM1 (CSPG9)      -----GTLHGICFNITILPVDNQVPEAFTNP----LKVTEGG---QSIISTEHILISDAD

FREM1 (CSPG10)     -----ASFPVYDLNITVYPVDNQPPSIAIGP----VFVVDEG--CSTALTVNHLSATDPD

FREM1 (CSPG11)     -----ERSAPMTVHISIRTADTNAPRVSWNT----GLSLLEG--QSRAITWEQFQVVDND

FREM1 (CSPG12)     -----LRTEHGVFEITLETVDRALPVVTRNK----GLRLAQG--AVGLLSPDLLQLTDPD

 

FREM1 (CSPG1)      SDNLKLMFVIAREPQHGVVRRA--GV-----TVD-------------QFSQRDVISEA-V

FREM1 (CSPG2)      SPREKIYYVFERLPQNGQLQLKI-GR-----DWVPL-S------PGMKCTQEEVDLNL-L

FREM1 (CSPG3)      IPQDALLFSITQKPRHGLLIDRGFSK-DFSENKQPA-NPHQKHAPVHSFSMELLKTGMRL

FREM1 (CSPG4)      ASDDYIFFNITKPPQAGEIMKKP--------------GPGLIGYPVHGFLQRDLFNGI-I

FREM1 (CSPG5)      SYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMK-V

FREM1 (CSPG6)      TEDDQIIFKILQGPKHGHLENTTT-----------------GEFIHEKFSQKDLNSKT-I

FREM1 (CSPG7)      DKPEELLYVITSPPRYGQIEYVH-----------------YPGVPITNFSQMDVVGQT-V

FREM1 (CSPG8)      TPKPLLVFNITKAPLQGYVTHLLD-----------------HTRPISSFTWKDLSDMQ-I

FREM1 (CSPG9)      TKLDNIDLSLRELPLHGRVEL----NG---------FPL----NSGGTFSWGDLHTLK-V

FREM1 (CSPG10)     TAADDLEFVLVSPPQFGYLENILPSVG---------FEKSNIGISIDSFQWKDMNAFH-I

FREM1 (CSPG11)     DIGA-VRLVTVGGLQHGWLTLR------------------GG--KGFLFTVADLQAGV-V

FREM1 (CSPG12)     TPAENLTFLLVQLPQHGQLYLW------------------GTGLLQHNFTQQDVDSKN-V

 

FREM1 (CSPG1)     TYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLH

FREM1 (CSPG2)     RYTHTGAMDSQ--NQDSFTFYLWDGN--------------------

FREM1 (CSPG3)     TYMHDDSES----LADDFTIQLSDG---------------------

FREM1 (CSPG4)     YYRHFGGEI----FEDSFQFVLWDSHEPP-----------------

FREM1 (CSPG5)     AYMPPMQDIGPHCRDVQFTFSVSNQHG-------------------

FREM1 (CSPG6)     LYIINPSL---EVNSDTVEFQIMDPTGN------------------

FREM1 (CSPG7)     CYVHKSKV---TVSSDRFRFIISNG---------------------

FREM1 (CSPG8)     AYQPPNSSH-SERRHDEVELEVYDFFF-------------------

FREM1 (CSPG9)     RYQHDGT----EVLQDDLLLEVTDG---------------------

FREM1 (CSPG10)    NYVQSRHLR-IEPTADQFTVYVTDGK--------------------

FREM1 (CSPG11)    RYHHDDS----DSTKDFVVFRIFDG---------------------

FREM1 (CSPG12)    AYRHSGG----DSQTDCFTFMATDGTNQGFIVNGR-----------

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CALX-BETA DOMAIN

FREM1     ATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVFEVILN

CTLD

FREM1                 KSCPAGWHQHSGYCHILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMRWLWDIGGRKSFWIGLNDQVHAGHWEWIGGEPVAFTN

   

                     GRRGPSQRSKLGKSCVLVQRQGKWQTKDCRRAKPHNYVCSRKL

 

CONSERVED CORE RESIDUES

 

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This page last updated:	Wednesday, 01 January 2014	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk